Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 3A
Ligand
BDBM50060688
Substrate
n/a
Meas. Tech.
ChEMBL_592418 (CHEMBL1037804)
Ki
0.81±n/a nM
Citation
 Butini, S; Budriesi, R; Hamon, M; Morelli, E; Gemma, S; Brindisi, M; Borrelli, G; Novellino, E; Fiorini, I; Ioan, P; Chiarini, A; Cagnotto, A; Mennini, T; Fracasso, C; Caccia, S; Campiani, G Novel, potent, and selective quinoxaline-based 5-HT(3) receptor ligands. 1. Further structure-activity relationships and pharmacological characterization. J Med Chem 52:6946-50 (2009) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 3A
Synonyms:
Zacopride site-R | 5-hydroxytryptamine receptor 3A | 5-HT3 | 5HT3A_RAT | Htr3a | 5ht3 | Htr3 | Serotonin (5-HT) receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
55428.70
Organism:
Rat
Description:
5-HT3 HTR3A RAT::P35563
Residue:
483
Sequence:
MPLCIPQVLLALFLSVLIAQGEGSRRRATQAHSTTQPALLRLSDHLLANYKKGVRPVRDWRKPTLVSIDVIMYAILNVDEKNQVLTTYIWYRQFWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPSIPYVYVHHQGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRTPEEVRSDKSIFINQGEWELLGVFTKFQEFSIETSNSYAEMKFYVVIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVQLVHKQDLQRPVPDWLRHLVLDRIAWLLCLGEQPMAHRPPATFQANKTDDCSAMGNHCSHVGSPQDLEKTSRSRDSPLPPPREASLAVRGLLQELSSIRHSLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHYS
  
Inhibitor
Name:
BDBM50060688
Synonyms:
7-Fluoro-4-(4-methyl-piperazin-1-yl)-pyrrolo[1,2-a]quinoxaline | 7-fluoro-4-(4-methylpiperazin-1-yl)pyrrolo[1,2-a]quinoxaline | CHEMBL341474
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
CN1CCN(CC1)c1nc2cc(F)ccc2n2cccc12
Structure:
Search PDB for entries with ligand similarity: