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Target
5-hydroxytryptamine receptor 3A
Ligand
BDBM50060685
Substrate
n/a
Meas. Tech.
ChEMBL_592422 (CHEMBL1037808)
Kd
64.57±n/a nM
Citation
 Butini, S; Budriesi, R; Hamon, M; Morelli, E; Gemma, S; Brindisi, M; Borrelli, G; Novellino, E; Fiorini, I; Ioan, P; Chiarini, A; Cagnotto, A; Mennini, T; Fracasso, C; Caccia, S; Campiani, G Novel, potent, and selective quinoxaline-based 5-HT(3) receptor ligands. 1. Further structure-activity relationships and pharmacological characterization. J Med Chem 52:6946-50 (2009) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 3A
Synonyms:
Serotonin 3a (5-HT3a) receptor | 5-hydroxytryptamine receptor 3A | 5-HT3 | 5HT3A_CAVPO | HTR3A | 5HT3R | HTR3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
55657.07
Organism:
Guinea pig
Description:
5-HT3 HTR3A GUINEA PIG::O70212
Residue:
490
Sequence:
MVLWLQLALLALLLPTSLAQGEVRGKGTAQAHNSTRPALQRLSDHLLADYRKSVRPVRDWRKPTTVSIDAIVYAILSVDEKNQVLTTYIWYRQFWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDKSVFMNQGEWELLGVLTEFLEFSDRESRGSFAEMKFYVVIRRRPLFYAVTLLLPSIFLMIVDIVGFYLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLISVYFVVCMALLVISLAETILIVRLVHKQDLQQPVPLWLRHLVLERIAGLLCLGEQLTSHRGPATLQATKTDDFSGSTLLPAMGNHCGPLGGPQDLEKTSRGRGSPPPPPREASLAMCGLLQELASIRHFLEKREETREVARDWLRVGSVLDKLLFRVYLLAVLAYSITLVTLWSVWHYA
  
Inhibitor
Name:
BDBM50060685
Synonyms:
9-fluoro-4-(4-methylpiperazin-1-yl)pyrrolo[1,2-a]quinoxaline | 9-Fluoro-4-(4-methyl-piperazin-1-yl)-pyrrolo[1,2-a]quinoxaline | CHEMBL124886
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
CN1CCN(CC1)c1nc2cccc(F)c2n2cccc12
Structure:
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