Reaction Details Report a problem with these data
Target
Synaptic vesicular amine transporter
Ligand
BDBM50017701
Substrate
n/a
Meas. Tech.
ChEMBL_591961 (CHEMBL1047524)
Ki
54±n/a nM
Citation
 Vartak, AP; Nickell, JR; Chagkutip, J; Dwoskin, LP; Crooks, PA Pyrrolidine analogues of lobelane: relationship of affinity for the dihydrotetrabenazine binding site with function of the vesicular monoamine transporter 2 (VMAT2). J Med Chem 52:7878-82 (2009) [PubMed]  Article 
Target
Name:
Synaptic vesicular amine transporter
Synonyms:
VAT2 | Vesicular amine transporter 2 | Monoamine transporter | Solute carrier family 18 member 2 | Synaptic vesicular amine transporter | VMAT2_RAT | Slc18a2 | Svat | Vmat2 | Vesicular monoamine transporter 2 (VMAT2)
Type:
Protein
Mol. Mass.:
55689.58
Organism:
Rat
Description:
Q01827
Residue:
515
Sequence:
MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEIQTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPSEDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEKMAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD
  
Inhibitor
Name:
BDBM50017701
Synonyms:
3-isobutyl-9,10-dimethoxy-3,4,6,7-tetrahydro-1H-pyrido[2,1-a]isoquinolin-2(11bH)-one | 3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-pyrido[2,1-a]isoquinolin-2-one | CHEMBL117785 | TETRABENAZINE | Tetrabenazine (TBZ)
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
COc1cc2CCN3CC(CC(C)C)C(=O)CC3c2cc1OC
Structure:
Search PDB for entries with ligand similarity: