Reaction Details Report a problem with these data
Target
Galanin receptor type 2
Ligand
BDBM50273370
Substrate
n/a
Meas. Tech.
ChEMBL_610350 (CHEMBL1072082)
Ki
1.8±n/a nM
Citation
 Robertson, CR; Scholl, EA; Pruess, TH; Green, BR; White, HS; Bulaj, G Engineering galanin analogues that discriminate between GalR1 and GalR2 receptor subtypes and exhibit anticonvulsant activity following systemic delivery. J Med Chem 53:1871-5 (2010) [PubMed]  Article 
Target
Name:
Galanin receptor type 2
Synonyms:
Galanin receptor type 2 (GAL2-R) (GALR2). | Galanin receptor 2 | Galanin R2 | Galanin receptor type 2 | GALR2_HUMAN | GALR2 | GALNR2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41724.40
Organism:
Human
Description:
Galanin R2 GALR2 HUMAN::O43603
Residue:
387
Sequence:
MNVSGCPGAGNASQAGGGGGWHPEAVIVPLLFALIFLVGTVGNTLVLAVLLRGGQAVSTTNLFILNLGVADLCFILCCVPFQATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLANLTVCHPAWSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRAKRKVTRMILIVAALFCLCWMPHHALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGFRTICAGLLGRAPGRASGRVCAAARGTHSGSVLERESSDLLHMSEAAGALRPCPGASQPCILEPCPGPSWQGPKAGDSILTVDVA
  
Inhibitor
Name:
BDBM50273370
Synonyms:
CHEMBL503473 | M35 | Galanin (1-13)-bradikinin(2-9) | Galanin-(1-13)-bradykinin-(2-9)-amide | GWTLNSAGYLLGPPPGFSPFR-CONH2
Type:
Small organic molecule
Emp. Form.:
C107 H153 N27 O26
Mol. Mass.:
2233.52502
SMILES:
CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)CN)[C@@H](C)O)C(=O)NCC(=O)N4CCC[C@H]4C(=O)N5CCC[C@H]5C(=O)N6CCC[C@H]6C(=O)NCC(=O)N[C@@H](Cc7ccccc7)C(=O)N[C@@H](CO)C(=O)N8CCC[C@H]8C(=O)N[C@@H](Cc9ccccc9)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O |r|
Structure:
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