Reaction Details
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Aurora kinase A
Ligand
BDBM50316496
Substrate
n/a
Meas. Tech.
ChEMBL_630519 (CHEMBL1104791)
IC50
792±n/a nM
Citation
Adams, ND; Adams, JL; Burgess, JL; Chaudhari, AM; Copeland, RA; Donatelli, CA; Drewry, DH; Fisher, KE; Hamajima, T; Hardwicke, MA; Huffman, WF; Koretke-Brown, KK; Lai, ZV; McDonald, OB; Nakamura, H; Newlander, KA; Oleykowski, CA; Parrish, CA; Patrick, DR; Plant, R; Sarpong, MA; Sasaki, K; Schmidt, SJ; Silva, DJ; Sutton, D; Tang, J; Thompson, CS; Tummino, PJ; Wang, JC; Xiang, H; Yang, J; Dhanak, D Discovery of GSK1070916, a potent and selective inhibitor of Aurora B/C kinase. J Med Chem 53:3973-4001 (2010) [PubMed] Article More Info.:
Target
Name:
Aurora kinase A
Synonyms:
AURKA_HUMAN | AIRK1 | hARK1 | STK15 GN | STK6 | Serine/threonine-protein kinase 15 | Serine/threonine-protein kinase 6 | Synonyms=AIK | AURKA | Breast tumor-amplified kinase | STK15 | Serine/threonine kinase 15 | Breast-tumor-amplified kinase | Serine/threonine-protein kinase aurora-A | Aurora kinase A (AURKA) | AYK1 | aurora-2 | AIK | BTAK | ARK-1 | Aurora kinase A (AURA) | ARK1 | Aurora/IPL1-related kinase 1 | Aurora 2 | Aurora kinase A (Aurora-2) | Aurora-related kinase 1 | Aurora kinase A (Aurora A) | Serine/threonine-protein kinase aurora A | IAK1 | AURA
Type:
Serine/threonine-protein kinase
Mol. Mass.:
45830.98
Organism:
Human
Description:
O14965
Residue:
403
Sequence:
MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRIPLQAQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
Inhibitor
Name:
BDBM50316496
Synonyms:
N-{4-[1-(2-Hydroxyethyl)-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-3-yl]phenyl}-N'-phenylurea | CHEMBL1099010
Type:
Small organic molecule
Emp. Form.:
C25 H22 N6 O2
Mol. Mass.:
438.48118
SMILES:
OCCn1cc(c(n1)-c1ccc(NC(=O)Nc2ccccc2)cc1)-c1ccnc2[nH]ccc12
Structure:
