Reaction Details
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Aurora kinase A
Ligand
BDBM31093
Substrate
n/a
Meas. Tech.
ChEMBL_630523 (CHEMBL1104795)
IC50
4±n/a nM
Citation
Adams, ND; Adams, JL; Burgess, JL; Chaudhari, AM; Copeland, RA; Donatelli, CA; Drewry, DH; Fisher, KE; Hamajima, T; Hardwicke, MA; Huffman, WF; Koretke-Brown, KK; Lai, ZV; McDonald, OB; Nakamura, H; Newlander, KA; Oleykowski, CA; Parrish, CA; Patrick, DR; Plant, R; Sarpong, MA; Sasaki, K; Schmidt, SJ; Silva, DJ; Sutton, D; Tang, J; Thompson, CS; Tummino, PJ; Wang, JC; Xiang, H; Yang, J; Dhanak, D Discovery of GSK1070916, a potent and selective inhibitor of Aurora B/C kinase. J Med Chem 53:3973-4001 (2010) [PubMed] Article More Info.:
Target
Name:
Aurora kinase A
Synonyms:
AURKA_HUMAN | AIRK1 | hARK1 | STK15 GN | STK6 | Serine/threonine-protein kinase 15 | Serine/threonine-protein kinase 6 | Synonyms=AIK | AURKA | Breast tumor-amplified kinase | STK15 | Serine/threonine kinase 15 | Breast-tumor-amplified kinase | Serine/threonine-protein kinase aurora-A | Aurora kinase A (AURKA) | AYK1 | aurora-2 | AIK | BTAK | ARK-1 | Aurora kinase A (AURA) | ARK1 | Aurora/IPL1-related kinase 1 | Aurora 2 | Aurora kinase A (Aurora-2) | Aurora-related kinase 1 | Aurora kinase A (Aurora A) | Serine/threonine-protein kinase aurora A | IAK1 | AURA
Type:
Serine/threonine-protein kinase
Mol. Mass.:
45830.98
Organism:
Human
Description:
O14965
Residue:
403
Sequence:
MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRIPLQAQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
Inhibitor
Name:
BDBM31093
Synonyms:
cid_11712649 | 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-chloranyl-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid | BDBM31832 | 4-[[9-chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid | MLN-8054 | CHEMBL259084
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
OC(=O)c1ccc(Nc2ncc3CN=C(c4cc(Cl)ccc4-c3n2)c2c(F)cccc2F)cc1 |c:13|
Structure:
