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Target
Melatonin receptor type 1B
Ligand
BDBM50316700
Substrate
n/a
Meas. Tech.
ChEMBL_632479 (CHEMBL1108343)
EC50
>10000±n/a nM
Citation
 Mésangeau, C; Pérès, B; Descamps-François, C; Chavatte, P; Audinot, V; Coumailleau, S; Boutin, JA; Delagrange, P; Bennejean, C; Renard, P; Caignard, DH; Berthelot, P; Yous, S Design, synthesis and pharmacological evaluation of novel naphthalenic derivatives as selective MT(1) melatoninergic ligands. Bioorg Med Chem 18:3426-36 (2010) [PubMed]  Article 
Target
Name:
Melatonin receptor type 1B
Synonyms:
MTNR1B | MTR1B_HUMAN | Mel-1B-R | Mel1b melatonin receptor | Melatonin 1B | Melatonin receptor | Melatonin receptor type 1B | Melatonin receptor type 2 (MT2)
Type:
Enzyme
Mol. Mass.:
40203.54
Organism:
Human
Description:
P49286
Residue:
362
Sequence:
MSENGSFANCCEAGGWAVRPGWSGAGSARPSRTPRPPWVAPALSAVLIVTTAVDVVGNLLVILSVLRNRKLRNAGNLFLVSLALADLVVAFYPYPLILVAIFYDGWALGEEHCKASAFVMGLSVIGSVFNITAIAINRYCYICHSMAYHRIYRRWHTPLHICLIWLLTVVALLPNFFVGSLEYDPRIYSCTFIQTASTQYTAAVVVIHFLLPIAVVSFCYLRIWVLVLQARRKAKPESRLCLKPSDLRSFLTMFVVFVIFAICWAPLNCIGLAVAINPQEMAPQIPEGLFVTSYLLAYFNSCLNAIVYGLLNQNFRREYKRILLALWNPRHCIQDASKGSHAEGLQSPAPPIIGVQHQADAL
  
Inhibitor
Name:
BDBM50316700
Synonyms:
CHEMBL1095832 | N-[2-(7-{4-[8-(2-Cyclopropanecarbonylaminoethyl)naphthalen-2-yloxy]butoxy}naphthalen-1-yl)ethyl]acetamide
Type:
Small organic molecule
Emp. Form.:
C34H38N2O4
Mol. Mass.:
538.6765
SMILES:
CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)C5CC5)c4c3)cc12
Structure:
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