Target
Melatonin receptor type 1A
Ligand
BDBM50316704
Substrate
n/a
Meas. Tech.
ChEMBL_632470 (CHEMBL1108334)
Ki
4±n/a nM
Citation
 Mésangeau, CPérès, BDescamps-François, CChavatte, PAudinot, VCoumailleau, SBoutin, JADelagrange, PBennejean, CRenard, PCaignard, DHBerthelot, PYous, S Design, synthesis and pharmacological evaluation of novel naphthalenic derivatives as selective MT(1) melatoninergic ligands. Bioorg Med Chem 18:3426-36 (2010) [PubMed]  Article 
Target
Name:
Melatonin receptor type 1A
Synonyms:
MTNR1A | MTNR1A protein | MTR1A_HUMAN | Mel-1A-R | Mel1a melatonin receptor | Melatonin 1A | Melatonin receptor | Melatonin receptor 1A | Melatonin receptor type 1 (MT1) | Melatonin receptor type 1A
Type:
Enzyme
Mol. Mass.:
39392.94
Organism:
Human
Description:
P48039
Residue:
350
Sequence:
MQGNGSALPNASQPVLRGDGARPSWLASALACVLIFTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLMSIFNNGWNLGYLHCQVSGFLMGLSVIGSIFNITGIAINRYCYICHSLKYDKLYSSKNSLCYVLLIWLLTLAAVLPNLRAGTLQYDPRIYSCTFAQSVSSAYTIAVVVFHFLVPMIIVIFCYLRIWILVLQVRQRVKPDRKPKLKPQDFRNFVTMFVVFVLFAICWAPLNFIGLAVASDPASMVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQNFRKEYRRIIVSLCTARVFFVDSSNDVADRVKWKPSPLMTNNNVVKVDSV
  
Inhibitor
Name:
BDBM50316704
Synonyms:
CHEMBL1095522 | N-[2-(7-{4-[3-(2-Acetylaminoethyl)-1H-indol-5-yloxy]-butoxy}-naphthalen-1-yl)ethyl]acetamide
Type:
Small organic molecule
Emp. Form.:
C30H35N3O4
Mol. Mass.:
501.6166
SMILES:
CC(=O)NCCc1c[nH]c2ccc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12
Structure:
Search PDB for entries with ligand similarity: