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Target
Bombesin receptor subtype-3
Ligand
BDBM50317453
Substrate
n/a
Meas. Tech.
ChEMBL_631840 (CHEMBL1111911)
EC50
1542±n/a nM
Citation
 Guo, C; Guzzo, PR; Hadden, M; Sargent, BJ; Yet, L; Kan, Y; Palyha, O; Kelly, TM; Guan, X; Rosko, K; Gagen, K; Metzger, JM; Dragovic, J; Lyons, K; Lin, LS; Nargund, RP Synthesis of 7-benzyl-5-(piperidin-1-yl)-6,7,8,9-tetrahydro-3H-pyrazolo[3,4-c][2,7]naphthyridin-1-ylamine and its analogs as bombesin receptor subtype-3 agonists. Bioorg Med Chem Lett 20:2785-9 (2010) [PubMed]  Article 
Target
Name:
Bombesin receptor subtype-3
Synonyms:
BRS-3 | BRS3 | BRS3_HUMAN | Bombesin 3 | Bombesin like receptor 3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44424.45
Organism:
Homo sapiens (Human)
Description:
Bombesin 3 BRS3 HUMAN::P32247
Residue:
399
Sequence:
MAQRQPHSPNQTLISITNDTESSSSVVSNDNTNKGWSGDNSPGIEALCAIYITYAVIISVGILGNAILIKVFFKTKSMQTVPNIFITSLAFGDLLLLLTCVPVDATHYLAEGWLFGRIGCKVLSFIRLTSVGVSVFTLTILSADRYKAVVKPLERQPSNAILKTCVKAGCVWIVSMIFALPEAIFSNVYTFRDPNKNMTFESCTSYPVSKKLLQEIHSLLCFLVFYIIPLSIISVYYSLIARTLYKSTLNIPTEEQSHARKQIESRKRIARTVLVLVALFALCWLPNHLLYLYHSFTSQTYVDPSAMHFIFTIFSRVLAFSNSCVNPFALYWLSKSFQKHFKAQLFCCKAERPEPPVADTSLTTLAVMGTVPGTGSIQMSEISVTSFTGCSVKQAEDRF
  
Inhibitor
Name:
BDBM50317453
Synonyms:
CHEMBL1098836 | N-(7-benzyl-5-(piperidin-1-yl)-6,7,8,9-tetrahydro-3H-pyrazolo[3,4-c][2,7]naphthyridin-1-yl)pivalamide
Type:
Small organic molecule
Emp. Form.:
C26H34N6O
Mol. Mass.:
446.5878
SMILES:
CC(C)(C)C(=O)Nc1n[nH]c2nc(N3CCCCC3)c3CN(Cc4ccccc4)CCc3c12
Structure:
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