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Target
Bombesin receptor subtype-3
Ligand
BDBM50317464
Substrate
n/a
Meas. Tech.
ChEMBL_631840
EC50
10000±n/a nM
Citation
 Guo, C; Guzzo, PR; Hadden, M; Sargent, BJ; Yet, L; Kan, Y; Palyha, O; Kelly, TM; Guan, X; Rosko, K; Gagen, K; Metzger, JM; Dragovic, J; Lyons, K; Lin, LS; Nargund, RP Synthesis of 7-benzyl-5-(piperidin-1-yl)-6,7,8,9-tetrahydro-3H-pyrazolo[3,4-c][2,7]naphthyridin-1-ylamine and its analogs as bombesin receptor subtype-3 agonists. Bioorg Med Chem Lett 20:2785-9 (2010) [PubMed]  Article  BDB Entry
Target
Name:
Bombesin receptor subtype-3
Synonyms:
BRS-3 | BRS3 | Bombesin 3 | Bombesin like receptor 3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44424.45
Organism:
Homo sapiens (Human)
Description:
Bombesin 3 BRS3 HUMAN::P32247
Residue:
399
Sequence:
MAQRQPHSPNQTLISITNDTESSSSVVSNDNTNKGWSGDNSPGIEALCAIYITYAVIISVGILGNAILIKVFFKTKSMQTVPNIFITSLAFGDLLLLLTCVPVDATHYLAEGWLFGRIGCKVLSFIRLTSVGVSVFTLTILSADRYKAVVKPLERQPSNAILKTCVKAGCVWIVSMIFALPEAIFSNVYTFRDPNKNMTFESCTSYPVSKKLLQEIHSLLCFLVFYIIPLSIISVYYSLIARTLYKSTLNIPTEEQSHARKQIESRKRIARTVLVLVALFALCWLPNHLLYLYHSFTSQTYVDPSAMHFIFTIFSRVLAFSNSCVNPFALYWLSKSFQKHFKAQLFCCKAERPEPPVADTSLTTLAVMGTVPGTGSIQMSEISVTSFTGCSVKQAEDRF
  
Inhibitor
Name:
BDBM50317464
Synonyms:
7-(4-methoxybenzyl)-5-(piperidin-1-yl)-6,7,8,9-tetrahydro-3H-pyrazolo[3,4-c][2,7]naphthyridin-1-amine | CHEMBL1096531
Type:
Small organic molecule
Emp. Form.:
C22H28N6O
Mol. Mass.:
392.4973
SMILES:
COc1ccc(CN2CCc3c(C2)c(nc2[nH]nc(N)c32)N2CCCCC2)cc1
Structure:
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