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Target
Acetylcholinesterase
Ligand
BDBM8961
Substrate
n/a
Meas. Tech.
ChEMBL_633736 (CHEMBL1119107)
IC50
27±n/a nM
Citation
 de Los Ríos, C; Egea, J; Marco-Contelles, J; León, R; Samadi, A; Iriepa, I; Moraleda, I; Gálvez, E; García, AG; López, MG; Villarroya, M; Romero, A Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1,8-naphthyridine derivatives. J Med Chem 53:5129-43 (2010) [PubMed]  Article 
Target
Name:
Acetylcholinesterase
Synonyms:
Acetylcholinesterase (AChE) | Acetylcholinesterase precursor | ACES_BOVIN | ACHE
Type:
Enzyme
Mol. Mass.:
67659.62
Organism:
Bovine
Description:
n/a
Residue:
613
Sequence:
MRPPWCPLHTPSLTPPLLLLLFLIGGGAEAEGPEDPELLVMVRGGRLRGLRLMAPRGPVSAFLGIPFAEPPVGPRRFLPPEPKRPWPGVLNATAFQSVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPSSPTPVLVWIYGGGFYSGASSLDVYDGRFLTQAEGTVLVSMNYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATVGVGEARRRATLLARLVGCPPGGAGGNDTELVACLRARPAQDLVDHEWRVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVGVVKDEGSYFLVYGAPGFSKDNESLISRAQFLAGVRVGVPQASDLAAEAVVLHYTDWLHPEDPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYIFEHRASTLSWPLWMGVPHGYEIEFIFGLPLEPSLNYTIEERTFAQRLMRYWANFARTGDPNDPRDPKAPQWPPYTAGAQQYVSLNLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKNQFDHYSKQDRCSDL
  
Inhibitor
Name:
BDBM8961
Synonyms:
CHEMBL95 | Cognex | cid_1935 | CHEMBL1337960 | 1,2,3,4-tetrahydroacridin-9-amine | Tracine | tacrine.HCl | 9-THA | 1,2,3,4-tetrahydro-9-acridinamine | 9-amino-1,2,3,4-tetrahydroacridine (THA) | Tacrine | US8999994, Tacrine
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: