Target
Serine/threonine-protein kinase Chk1
Ligand
BDBM50321649
Substrate
n/a
Meas. Tech.
ChEMBL_639904 (CHEMBL1173978)
IC50
5000±n/a nM
Citation
 Matthews, TPMcHardy, TKlair, SBoxall, KFisher, MCherry, MAllen, CEAddison, GJEllard, JAherne, GWWestwood, IMvan Montfort, RGarrett, MDReader, JCCollins, I Design and evaluation of 3,6-di(hetero)aryl imidazo[1,2-a]pyrazines as inhibitors of checkpoint and other kinases. Bioorg Med Chem Lett 20:4045-9 (2010) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase Chk1
Synonyms:
CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
54443.02
Organism:
Homo sapiens (Human)
Description:
gi_166295192
Residue:
476
Sequence:
MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDFSPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLLGTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRRNNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
  
Inhibitor
Name:
BDBM50321649
Synonyms:
3,6-di(1H-pyrazol-4-yl)imidazo[1,2-a]pyrimidine | CHEMBL1171532
Type:
Small organic molecule
Emp. Form.:
C12H9N7
Mol. Mass.:
251.2468
SMILES:
c1n[nH]cc1-c1cnc2ncc(cn12)-c1cn[nH]c1
Structure:
Search PDB for entries with ligand similarity: