Reaction Details Report a problem with these data
Target
Cysteinyl leukotriene receptor 1
Ligand
BDBM50323902
Substrate
n/a
Meas. Tech.
ChEMBL_647615 (CHEMBL1219966)
EC50
1300±n/a nM
Citation
 Dong, X; Wang, L; Huang, X; Liu, T; Wei, E; Du, L; Yang, B; Hu, Y Pharmacophore identification, synthesis, and biological evaluation of carboxylated chalcone derivatives as CysLT1 antagonists. Bioorg Med Chem 18:5519-27 (2010) [PubMed]  Article 
Target
Name:
Cysteinyl leukotriene receptor 1
Synonyms:
CLTR1_HUMAN | CYSLT1 | CYSLTR1 | Cysteinyl leukotriene D4 receptor | Cysteinyl leukotriene receptor | Cysteinyl leukotriene receptor 1 | HG55 | HMTMF81 | LTD4 receptor | Leukotriene Cysteinyl 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38565.16
Organism:
Homo sapiens (Human)
Description:
Leukotriene Cysteinyl 1 CYSLTR1 HUMAN::Q9Y271
Residue:
337
Sequence:
MDETGNLTVSSATCHDTIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDNQTKNHVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLHNETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRLSTFRKHSLSSVTYVPRKKASLPEKGEEICKV
  
Inhibitor
Name:
BDBM50323902
Synonyms:
(E)-2-(2-(3-(4-(4-(4-Chlorophenoxy)butoxy)phenyl)acryloyl)-5-fluorophenoxy)acetic acid | CHEMBL1213847
Type:
Small organic molecule
Emp. Form.:
C27H24ClFO6
Mol. Mass.:
498.927
SMILES:
OC(=O)COc1ccc(F)cc1C(=O)\C=C\c1ccc(OCCCCOc2ccc(Cl)cc2)cc1
Structure:
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