Reaction Details Report a problem with these data
Target
Outer membrane protein MIP
Ligand
BDBM50335229
Substrate
n/a
Meas. Tech.
ChEMBL_701873 (CHEMBL1657165)
IC50
>100000±n/a nM
Citation
 Juli, C; Sippel, M; Jäger, J; Thiele, A; Weiwad, M; Schweimer, K; Rösch, P; Steinert, M; Sotriffer, CA; Holzgrabe, U Pipecolic acid derivatives as small-molecule inhibitors of the Legionella MIP protein. J Med Chem 54:277-83 (2011) [PubMed]  Article 
Target
Name:
Outer membrane protein MIP
Synonyms:
MIP_LEGPN | Macrophage infectivity potentiator | PPIase | Peptidyl-prolyl cis-trans isomerase | Rotamase | mip
Type:
PROTEIN
Mol. Mass.:
24869.94
Organism:
Legionella pneumophila
Description:
ChEMBL_701873
Residue:
233
Sequence:
MKMKLVTAAVMGLAMSTAMAATDATSLATDKDKLSYSIGADLGKNFKNQGIDVNPEAMAKGMQDAMSGAQLALTEQQMKDVLNKFQKDLMAKRTAEFNKKADENKVKGEAFLTENKNKPGVVVLPSGLQYKVINAGNGVKPGKSDTVTVEYTGRLIDGTVFDSTEKTGKPATFQVSQVIPGWTEALQLMPAGSTWEIYVPSGLAYGPRSVGGPIGPNETLIFKIHLISVKKSS
  
Inhibitor
Name:
BDBM50335229
Synonyms:
3-(pyridin-3-yl)propyl 1-(3-aminophenylsulfonyl)piperidine-2-carboxylate | CHEMBL1650950
Type:
Small organic molecule
Emp. Form.:
C20H25N3O4S
Mol. Mass.:
403.495
SMILES:
Nc1cccc(c1)S(=O)(=O)N1CCCCC1C(=O)OCCCc1cccnc1
Structure:
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