Target
Translocator protein
Ligand
BDBM50143220
Substrate
n/a
Meas. Tech.
ChEMBL_702767 (CHEMBL1655210)
Ki
1.4±n/a nM
Citation
 Pike, VWTaliani, SLohith, TGOwen, DRPugliesi, IDa Pozzo, EHong, JZoghbi, SSGunn, RNParker, CARabiner, EAFujita, MInnis, RBMartini, CDa Settimo, F Evaluation of novel N1-methyl-2-phenylindol-3-ylglyoxylamides as a new chemotype of 18 kDa translocator protein-selective ligand suitable for the development of positron emission tomography radioligands. J Med Chem 54:366-73 (2011) [PubMed]  Article 
Target
Name:
Translocator protein
Synonyms:
Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:
Mitochondrion membrane protein
Mol. Mass.:
18945.84
Organism:
Rattus norvegicus (rat)
Description:
Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:
169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAMGYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVATATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
  
Inhibitor
Name:
BDBM50143220
Synonyms:
CHEMBL294625 | N,N-Dihexyl-2-oxo-2-(2-phenyl-1H-indol-3-yl)-acetamide | N,N-dihexyl-2-oxo-2-(2-phenyl-1H-indol-3-yl)acetamide
Type:
Small organic molecule
Emp. Form.:
C28H36N2O2
Mol. Mass.:
432.5976
SMILES:
CCCCCCN(CCCCCC)C(=O)C(=O)c1c([nH]c2ccccc12)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: