Reaction Details Report a problem with these data
Target
D(1A) dopamine receptor
Ligand
BDBM50336860
Substrate
n/a
Meas. Tech.
ChEMBL_718439 (CHEMBL1680103)
Ki
>5000±n/a nM
Citation
 Sromek, AW; Si, YG; Zhang, T; George, SR; Seeman, P; Neumeyer, JL Synthesis and Biological Evaluation of N-Fluoroalkyl and 2-Fluoroalkoxy Substituted Aporphines: Potential PET Ligands for Dopamine D(2) Receptors. ACS Med Chem Lett 2:189-194 (2011) [PubMed]  Article 
Target
Name:
D(1A) dopamine receptor
Synonyms:
DA D1 receptor | DOPAMINE D1 | Dopamine D1 receptor | Dopamine D1 receptor (D1R) | Dopamine D1A | DRD1_HUMAN | DRD1
Type:
Enzyme
Mol. Mass.:
49303.43
Organism:
Human
Description:
P21728
Residue:
446
Sequence:
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
  
Inhibitor
Name:
BDBM50336860
Synonyms:
N-propyl-2-fluoropropanoxy-11-monohydroxy aporphine | CHEMBL1672309
Type:
Small organic molecule
Emp. Form.:
C22H26FNO2
Mol. Mass.:
n/a
SMILES:
CCCN1CCc2cc(OCCCF)cc-3c2[C@H]1Cc1cccc(O)c-31 |r|
Structure:
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