Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 3A
Ligand
BDBM50379017
Substrate
n/a
Meas. Tech.
ChEMBL_809641 (CHEMBL2015860)
Ki
178±n/a nM
Citation
 Cappelli, A; Manini, M; Paolino, M; Gallelli, A; Anzini, M; Mennuni, L; Del Cadia, M; De Rienzo, F; Menziani, MC; Vomero, S Bivalent Ligands for the Serotonin 5-HT3 Receptor. ACS Med Chem Lett 2:571-576 (2011) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 3A
Synonyms:
5-HT3 | 5-hydroxytryptamine receptor 3A | 5HT3A_RAT | 5ht3 | Htr3 | Htr3a | Serotonin (5-HT) receptor | Zacopride site-R
Type:
Enzyme Catalytic Domain
Mol. Mass.:
55428.70
Organism:
RAT
Description:
5-HT3 HTR3A RAT::P35563
Residue:
483
Sequence:
MPLCIPQVLLALFLSVLIAQGEGSRRRATQAHSTTQPALLRLSDHLLANYKKGVRPVRDWRKPTLVSIDVIMYAILNVDEKNQVLTTYIWYRQFWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPSIPYVYVHHQGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRTPEEVRSDKSIFINQGEWELLGVFTKFQEFSIETSNSYAEMKFYVVIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVQLVHKQDLQRPVPDWLRHLVLDRIAWLLCLGEQPMAHRPPATFQANKTDDCSAMGNHCSHVGSPQDLEKTSRSRDSPLPPPREASLAVRGLLQELSSIRHSLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHYS
  
Inhibitor
Name:
BDBM50379017
Synonyms:
CHEMBL2011595
Type:
Small organic molecule
Emp. Form.:
C27H41N5O3
Mol. Mass.:
483.6461
SMILES:
CN1CCN(CC1)c1nc2ccccc2c(C(=O)NCCCCCCNC(=O)OC(C)(C)C)c1C
Structure:
Search PDB for entries with ligand similarity: