Target
Carbonic anhydrase 1
Ligand
BDBM50380140
Substrate
n/a
Meas. Tech.
ChEMBL_811721 (CHEMBL2014296)
Kd
4500±n/a nM
Citation
 Capkauskaite, EZubriene, ABaranauskiene, LTamulaitiene, GManakova, EKairys, VGražulis, STumkevicius, SMatulis, D Design of [(2-pyrimidinylthio)acetyl]benzenesulfonamides as inhibitors of human carbonic anhydrases. Eur J Med Chem 51:259-70 (2012) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 1
Synonyms:
CA-I | CA1 | CAB | CAH1_HUMAN | Carbonate dehydratase I | Carbonic anhydrase | Carbonic anhydrase 1 (CA I) | Carbonic anhydrase 1 (CA-I) | Carbonic anhydrase 1 (Recombinant CA I) | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase B | Carbonic anhydrase I | Carbonic anhydrase I (CA I) | Carbonic anhydrase I (CA-I) | Carbonic anhydrase I (CAI) | Carbonic anhydrase I (hCA I) | Carbonic anhydrase isoenzyme I (hCA I) | hCA
Type:
Enzyme
Mol. Mass.:
28873.37
Organism:
Homo sapiens (Human)
Description:
P00915
Residue:
261
Sequence:
MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF
  
Inhibitor
Name:
BDBM50380140
Synonyms:
CHEMBL2011155 | carbonic anhydrase (CA) inhibitors, benzenesulphonamide ligand, 10
Type:
Small organic molecule
Emp. Form.:
C12H10ClN3O3S2
Mol. Mass.:
343.809
SMILES:
NS(=O)(=O)c1cc(ccc1Cl)C(=O)CSc1ncccn1
Structure:
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