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Target
Bombesin receptor subtype-3
Ligand
BDBM50381916
Substrate
n/a
Meas. Tech.
ChEMBL_817750 (CHEMBL2027398)
EC50
76±n/a nM
Citation
 Chobanian, HR; Guo, Y; Liu, P; Lanza, TJ; Chioda, M; Chang, L; Kelly, TM; Kan, Y; Palyha, O; Guan, XM; Marsh, DJ; Metzger, JM; Raustad, K; Wang, SP; Strack, AM; Gorski, JN; Miller, R; Pang, J; Lyons, K; Dragovic, J; Ning, JG; Schafer, WA; Welch, CJ; Gong, X; Gao, YD; Hornak, V; Reitman, ML; Nargund, RP; Lin, LS The design and synthesis of potent, selective benzodiazepine sulfonamide bombesin receptor subtype 3 (BRS-3) agonists with an increased barrier of atropisomerization. Bioorg Med Chem 20:2845-9 (2012) [PubMed]  Article 
Target
Name:
Bombesin receptor subtype-3
Synonyms:
BRS3_MOUSE | Brs3
Type:
PROTEIN
Mol. Mass.:
44239.49
Organism:
Mouse
Description:
ChEMBL_1445902
Residue:
399
Sequence:
MSQRQSQSPNQTLISITNDTETSSSVVSNDTTHKGWTGDNSPGIEALCAIYITYAGIISVGILGNAILIKVFFKTKSMQTVPNIFITSLAFGDLLLLLTCVPVDATHYLAEGWLFGKVGCKVLSFIRLTSVGVSVFTLTILSADRYKAVVKPLERQPPNAILKTCAKAGGIWIVSMIFALPEAIFSNVYTFQDPNRNVTFESCNSYPISERLLQEIHSLLCFLVFYIIPLSIISVYYSLIARTLYKSTLNIPTEEQSHARKQIESRKRIAKTVLVLVALFALCWLPNHLLYLYHSFTYESYANHSDVPFVIIIFSRVLAFSNSCVNPFALYWLSKTFQQHFKAQLCCLKAEQPEPPLGDIPLNNLTVMGRVPATGSAHVSEISVTLFSGSSAKKGEDKV
  
Inhibitor
Name:
BDBM50381916
Synonyms:
CHEMBL2023111
Type:
Small organic molecule
Emp. Form.:
C29H25F6N5O5S
Mol. Mass.:
n/a
SMILES:
CC(C)(O)c1nc(no1)C1(CCC1)c1cccc2Nc3nc(ccc3CN(c12)S(=O)(=O)c1ccc(OC(F)(F)F)cc1)C(F)(F)F
Structure:
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