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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM50383267
Substrate
n/a
Meas. Tech.
ChEMBL_819566 (CHEMBL2033650)
IC50
6000±n/a nM
Citation
 Good, AC; Liu, J; Hirth, B; Asmussen, G; Xiang, Y; Biemann, HP; Bishop, KA; Fremgen, T; Fitzgerald, M; Gladysheva, T; Jain, A; Jancsics, K; Metz, M; Papoulis, A; Skerlj, R; Stepp, JD; Wei, RR Implications of promiscuous Pim-1 kinase fragment inhibitor hydrophobic interactions for fragment-based drug design. J Med Chem 55:2641-8 (2012) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM50383267
Synonyms:
CHEMBL2032370
Type:
Small organic molecule
Emp. Form.:
C10H5NO2
Mol. Mass.:
171.1522
SMILES:
O=C1C(C#N)C(=O)c2ccccc12
Structure:
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