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Target
14-3-3 protein gamma
Ligand
BDBM50383921
Substrate
n/a
Meas. Tech.
ChEMBL_819533
IC50
10000±n/a nM
Citation
 Yan, YM; Dai, HQ; Du, Y; Schneider, B; Guo, H; Li, DP; Zhang, LX; Fu, H; Dong, XP; Cheng, YX Identification of blapsins A and B as potent small-molecule 14-3-3 inhibitors from the insect Blaps japanensis. Bioorg Med Chem Lett 22:4179-81 (2012) [PubMed]  Article  BDB Entry
Target
Name:
14-3-3 protein gamma
Synonyms:
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
Type:
Enzyme Catalytic Domain
Mol. Mass.:
28289.17
Organism:
Homo sapiens (Human)
Description:
gi_21464101
Residue:
247
Sequence:
MVDREQLVQKARLAEQAERYDDMAAAMKNVTELNEPLSNEERNLLSVAYKNVVGARRSSWRVISSIEQKTSADGNEKKIEMVRAYREKIEKELEAVCQDVLSLLDNYLIKNCSETQYESKVFYLKMKGDYYRYLAEVATGEKRATVVESSEKAYSEAHEISKEHMQPTHPIRLGLALNYSVFYYEIQNAPEQACHLAKTAFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDQQDDDGGEGNN
  
Inhibitor
Name:
BDBM50383921
Synonyms:
CHEMBL2031676
Type:
Small organic molecule
Emp. Form.:
C15H14O5
Mol. Mass.:
274.2687
SMILES:
Oc1ccc(cc1O)C1OCCc2cc(O)c(O)cc12
Structure:
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