Reaction Details Report a problem with these data
Target
Cytochrome P450 2C19
Ligand
BDBM50384443
Substrate
n/a
Meas. Tech.
ChEMBL_821758 (CHEMBL2039055)
IC50
>50118.72±n/a nM
Citation
 Jin, J; Morales-Ramos, A; Eidam, P; Mecom, J; Li, Y; Brooks, C; Hilfiker, M; Zhang, D; Wang, N; Shi, D; Tseng, PS; Wheless, K; Budzik, B; Evans, K; Jaworski, JP; Jugus, J; Leon, L; Wu, C; Pullen, M; Karamshi, B; Rao, P; Ward, E; Laping, N; Evans, C; Leach, C; Holt, D; Su, X; Morrow, D; Fries, H; Thorneloe, K; Edwards, R Novel 3-Oxazolidinedione-6-aryl-pyridinones as Potent, Selective, and Orally Active EP3 Receptor Antagonists. ACS Med Chem Lett 1:316-320 (2010) [PubMed]  Article 
Target
Name:
Cytochrome P450 2C19
Synonyms:
CP2CJ_HUMAN | CYP2C19 | CYPIIC17 | CYPIIC19 | Cytochrome P450 2C19 (CYP2C19) | Cytochrome P450 2C19 [I331V] | Mephenytoin 4-hydroxylase | P450-11A | P450-254C
Type:
Enzyme
Mol. Mass.:
55935.47
Organism:
Homo sapiens (Human)
Description:
P33261
Residue:
490
Sequence:
MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQLCFIPV
  
Inhibitor
Name:
BDBM50384443
Synonyms:
CHEMBL1770317
Type:
Small organic molecule
Emp. Form.:
C21H18N2O4
Mol. Mass.:
362.3786
SMILES:
CC(C)C1(OC(O)=NC1=O)c1ccc([nH]c1=O)-c1ccc2ccccc2c1 |c:6|
Structure:
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