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Target
Prostaglandin E2 receptor EP3 subtype
Ligand
BDBM50384443
Substrate
n/a
Meas. Tech.
ChEMBL_821762 (CHEMBL2039059)
Ki
10±n/a nM
Citation
 Jin, J; Morales-Ramos, A; Eidam, P; Mecom, J; Li, Y; Brooks, C; Hilfiker, M; Zhang, D; Wang, N; Shi, D; Tseng, PS; Wheless, K; Budzik, B; Evans, K; Jaworski, JP; Jugus, J; Leon, L; Wu, C; Pullen, M; Karamshi, B; Rao, P; Ward, E; Laping, N; Evans, C; Leach, C; Holt, D; Su, X; Morrow, D; Fries, H; Thorneloe, K; Edwards, R Novel 3-Oxazolidinedione-6-aryl-pyridinones as Potent, Selective, and Orally Active EP3 Receptor Antagonists. ACS Med Chem Lett 1:316-320 (2010) [PubMed]  Article 
Target
Name:
Prostaglandin E2 receptor EP3 subtype
Synonyms:
PE2R3_HUMAN | PGE receptor, EP3 subtype | PGE2-R | PTGER3 | Prostaglandin E2 receptor | Prostaglandin E2 receptor EP3 subtype | Prostaglandin E2 receptor EP3 subtype (EP3) | Prostaglandin E2 receptor EP3A subtype (EP3A) | Prostaglandin E2 receptor EP3D subtype (EP3D) | Prostanoid EP3 receptor
Type:
Enzyme
Mol. Mass.:
43335.03
Organism:
Homo sapiens (Human)
Description:
P43115
Residue:
390
Sequence:
MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLLTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRWEHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLLALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRYHTNNYASSSTSLPCQCSSTLMWSDHLER
  
Inhibitor
Name:
BDBM50384443
Synonyms:
CHEMBL1770317
Type:
Small organic molecule
Emp. Form.:
C21H18N2O4
Mol. Mass.:
362.3786
SMILES:
CC(C)C1(OC(O)=NC1=O)c1ccc([nH]c1=O)-c1ccc2ccccc2c1 |c:6|
Structure:
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