Reaction Details Report a problem with these data
Target
Prostaglandin E2 receptor EP3 subtype
Ligand
BDBM50385129
Substrate
n/a
Meas. Tech.
ChEMBL_822928 (CHEMBL2038099)
Ki
>10000±n/a nM
Citation
 Kambe, T; Maruyama, T; Nakai, Y; Oida, H; Maruyama, T; Abe, N; Nishiura, A; Nakai, H; Toda, M Synthesis and evaluation of¿-lactam analogs of PGE2 as EP4 and EP2/EP4 agonists. Bioorg Med Chem 20:3502-22 (2012) [PubMed]  Article 
Target
Name:
Prostaglandin E2 receptor EP3 subtype
Synonyms:
Prostaglandin E2 receptor EP3 isoform alpha | PGE receptor, EP3 isoform alpha | Prostaglandin E3 | PE2R3_MOUSE | Ptger3 | Ptgerep3 | Prostanoid EP3 receptor
Type:
G-protein coupled receptor
Mol. Mass.:
40092.50
Organism:
Mouse
Description:
n/a
Residue:
365
Sequence:
MASMWAPEHSAEAHSNLSSTTDDCGSVSVAFPITMMVTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTSPVVILVYLSQRRWEQLDPSGRLCTFFGLTMTVFGLSSLLVASAMAVERALAIRAPHWYASHMKTRATPVLLGVWLSVLAFALLPVLGVGRYSVQWPGTWCFISTGPAGNETDPAREPGSVAFASAFACLGLLALVVTFACNLATIKALVSRCRAKAAVSQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQMSVEQCKTQMGKEKECNSFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRDHTNYASSSTSLPCPGSSALMWSDQLER
  
Inhibitor
Name:
BDBM50385129
Synonyms:
CHEMBL2036319
Type:
Small organic molecule
Emp. Form.:
C27H28N2O5S2
Mol. Mass.:
n/a
SMILES:
COc1ccc(cc1)-c1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSc2nc(cs2)C(O)=O)c1 |r|
Structure:
Search PDB for entries with ligand similarity: