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Target
Arachidonate 5-lipoxygenase-activating protein
Ligand
BDBM22334
Substrate
n/a
Meas. Tech.
ChEMBL_822749 (CHEMBL2040233)
IC50
110±n/a nM
Citation
 Banoglu, E; Çaliskan, B; Luderer, S; Eren, G; Özkan, Y; Altenhofen, W; Weinigel, C; Barz, D; Gerstmeier, J; Pergola, C; Werz, O Identification of novel benzimidazole derivatives as inhibitors of leukotriene biosynthesis by virtual screening targeting 5-lipoxygenase-activating protein (FLAP). Bioorg Med Chem 20:3728-41 (2012) [PubMed]  Article 
Target
Name:
Arachidonate 5-lipoxygenase-activating protein
Synonyms:
5-lipoxygenase activating protein | MK-886-binding protein | 5-lipoxygenase-activating protein (FLAP) | AL5AP_HUMAN | ALOX5AP | FLAP | 5-lipoxygenase/FLAP
Type:
Enzyme
Mol. Mass.:
18159.90
Organism:
Human
Description:
P20292
Residue:
161
Sequence:
MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNCVDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
  
Inhibitor
Name:
BDBM22334
Synonyms:
N-(3-phenoxycinnamyl)acetohydroxamic acid | BW A4C | CHEMBL314360 | JMC515449 Compound 7 | BW4C | N-hydroxy-N-[(2E)-3-(3-phenoxyphenyl)prop-2-en-1-yl]acetamide | BWA4C | BWA4C, 10
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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