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Target
Aldo-keto reductase family 1 member B10
Ligand
BDBM16452
Substrate
n/a
Meas. Tech.
ChEMBL_823524 (CHEMBL2045967)
IC50
2360±n/a nM
Citation
 Adeniji, AO; Twenter, BM; Byrns, MC; Jin, Y; Chen, M; Winkler, JD; Penning, TM Development of potent and selective inhibitors of aldo-keto reductase 1C3 (type 5 17ß-hydroxysteroid dehydrogenase) based on N-phenyl-aminobenzoates and their structure-activity relationships. J Med Chem 55:2311-23 (2012) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B10
Synonyms:
Aldo-keto reductase family 1 member B10 | Small intestine reductase | ARL-1 | hARP | Aldo-keto reductase family 1 member B10 (AKR1B10) | Aldose reductase-related protein | SI reductase | Aldose reductase-like | ARP | AK1BA_HUMAN | AKR1B10 | AKR1B11 | Aldo-keto reductase family member 1B10 (AKR1B10)
Type:
Protein
Mol. Mass.:
36024.67
Organism:
Human
Description:
O60218. 1ZUA; 4JII; 4GQ0
Residue:
316
Sequence:
MATFVELSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQEKIQEKAVKREDLFIVSKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSGDDLFPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALGVSNFSHFQIEKLLNKPGLKYKPVTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIKEIAAKHKKTAAQVLIRFHIQRNVIVIPKSVTPARIVENIQVFDFKLSDEEMATILSFNRNWRACNVLQSSHLEDYPFNAEY
  
Inhibitor
Name:
BDBM16452
Synonyms:
(4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl}-3,4-dihydrophthalazin-1-yl)acetic acid | 2-(4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl}-3,4-dihydrophthalazin-1-yl)acetic acid | Xedia | CHEMBL10372 | Alond | Zopolrestat
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: