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Target
Free fatty acid receptor 1
Ligand
BDBM50386651
Substrate
n/a
Meas. Tech.
ChEMBL_826836 (CHEMBL2051553)
Ki
6.2±n/a nM
Citation
 Mikami, S; Kitamura, S; Negoro, N; Sasaki, S; Suzuki, M; Tsujihata, Y; Miyazaki, T; Ito, R; Suzuki, N; Miyazaki, J; Santou, T; Kanzaki, N; Funami, M; Tanaka, T; Yasuma, T; Momose, Y Discovery of phenylpropanoic acid derivatives containing polar functionalities as potent and orally bioavailable G protein-coupled receptor 40 agonists for the treatment of type 2 diabetes. J Med Chem 55:3756-76 (2012) [PubMed]  Article 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1_RAT | Ffar1 | G-protein coupled receptor 40 | Gpr40
Type:
PROTEIN
Mol. Mass.:
31848.38
Organism:
Rattus norvegicus
Description:
ChEMBL_1511162
Residue:
300
Sequence:
MDLPPQLSFALYVSAFALGFPLNLLAIRGAVSHAKLRLTPSLVYTLHLACSDLLLAITLPLKAVEALASGVWPLPLPFCPVFALAHFAPLYAGGGFLAALSAGRYLGAAFPFGYQAIRRPCYSWGVCVAIWALVLCHLGLALGLEAPRGWVDNTTSSLGINIPVNGSPVCLEAWDPDSARPARLSFSILLFFLPLVITAFCYVGCLRALVHSGLSHKRKLRAAWVAGGALLTLLLCLGPYNASNVASFINPDLEGSWRKLGLITGAWSVVLNPLVTGYLGTGPGQGTICVTRTPRGTIQK
  
Inhibitor
Name:
BDBM50386651
Synonyms:
CHEMBL2048628
Type:
Small organic molecule
Emp. Form.:
C28H32FNO4
Mol. Mass.:
465.5564
SMILES:
CCOCCOc1cc(C)c(c(C)c1)-c1cccc(CNc2ccc(CCC(O)=O)c(F)c2)c1
Structure:
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