Reaction Details Report a problem with these data
Target
Eukaryotic translation initiation factor 4E
Ligand
BDBM50316305
Substrate
n/a
Meas. Tech.
ChEMBL_826735 (CHEMBL2051182)
IC50
15500±n/a nM
Citation
 Chen, X; Kopecky, DJ; Mihalic, J; Jeffries, S; Min, X; Heath, J; Deignan, J; Lai, S; Fu, Z; Guimaraes, C; Shen, S; Li, S; Johnstone, S; Thibault, S; Xu, H; Cardozo, M; Shen, W; Walker, N; Kayser, F; Wang, Z Structure-guided design, synthesis, and evaluation of guanine-derived inhibitors of the eIF4E mRNA-cap interaction. J Med Chem 55:3837-51 (2012) [PubMed]  Article 
Target
Name:
Eukaryotic translation initiation factor 4E
Synonyms:
Eukaryotic translation initation factor | IF4E_HUMAN | EIF4E | EIF4EL1 | EIF4F | Eukaryotic translation initiation factor 4E/Eukaryotic translation initiation factor 4E-binding protein 1 | Eukaryotic translation initiation factor 4E (eIF4E)
Type:
Protein
Mol. Mass.:
25095.44
Organism:
Human
Description:
P06730
Residue:
217
Sequence:
MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV
  
Inhibitor
Name:
BDBM50316305
Synonyms:
((2R,3S,4R,5R)-5-(2-amino-7-benzyl-6-oxo-1H-purin-1-ium-9(6H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate | CHEMBL1094975
Type:
Small organic molecule
Emp. Form.:
C17 H20 N5 O8 P
Mol. Mass.:
453.34316
SMILES:
Nc1nc2n(c[n+](Cc3ccccc3)c2c(=O)[nH]1)[C@@H]1O[C@H](COP(O)([O-])=O)[C@@H](O)[C@H]1O |r|
Structure:
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