Reaction Details Report a problem with these data
Target
Phosphoethanolamine N-methyltransferase
Ligand
BDBM50149893
Substrate
n/a
Meas. Tech.
ChEMBL_829173 (CHEMBL2059995)
IC50
460000±n/a nM
Citation
 Lee, SG; Alpert, TD; Jez, JM Crystal structure of phosphoethanolamine methyltransferase from Plasmodium falciparum in complex with amodiaquine. Bioorg Med Chem Lett 22:4990-3 (2012) [PubMed]  Article 
Target
Name:
Phosphoethanolamine N-methyltransferase
Synonyms:
PMT
Type:
PROTEIN
Mol. Mass.:
31038.21
Organism:
Plasmodium falciparum
Description:
ChEMBL_829173
Residue:
266
Sequence:
MTLIENLNSDKTFLENNQYTDEGVKVYEFIFGENYISSGGLEATKKILSDIELNENSKVLDIGSGLGGGCMYINEKYGAHTHGIDICSNIVNMANERVSGNNKIIFEANDILTKEFPENNFDLIYSRDAILHLSLENKNKLFQKCYKWLKPTGTLLITDYCATEKENWDDEFKEYVKQRKYTLITVEEYADILTACNFKNVVSKDLSDYWNQLLEVEHKYLHENKEEFLKLFSEKKFISLDDGWSRKIKDSKRKMQRWGYFKATKN
  
Inhibitor
Name:
BDBM50149893
Synonyms:
4-(6-Methoxy-quinolin-8-ylamino)-pentyl-ammonium | CHEMBL506 | PRIMAQUINE
Type:
Small organic molecule
Emp. Form.:
C15H22N3O
Mol. Mass.:
260.3541
SMILES:
COc1cc(NC(C)CCC[NH3+])c2ncccc2c1
Structure:
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