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Target
Squalene synthase
Ligand
BDBM50388354
Substrate
n/a
Meas. Tech.
ChEMBL_829805 (CHEMBL2061324)
IC50
220±n/a nM
Citation
 Ichikawa, M; Ohtsuka, M; Ohki, H; Haginoya, N; Itoh, M; Sugita, K; Usui, H; Suzuki, M; Terayama, K; Kanda, A Discovery of novel tricyclic compounds as squalene synthase inhibitors. Bioorg Med Chem 20:3072-93 (2012) [PubMed]  Article 
Target
Name:
Squalene synthase
Synonyms:
FDFT_RAT | FPP:FPP farnesyltransferase | Farnesyl-diphosphate farnesyltransferase | Fdft1 | SQS | SS | Squalene synthetase
Type:
PROTEIN
Mol. Mass.:
48109.41
Organism:
Rattus norvegicus
Description:
ChEMBL_1336736
Residue:
416
Sequence:
MEFVKCLGHPEEFYNLLRFRMGGRRNFIPKMDRNSLSNSLKTCYKYLDQTSRSFAAVIQALDGDIRHAVCVFYLILRAMDTVEDDMAISVEKKIPLLRNFHTFLYEPEWRFTESKEKHRVVLEDFPTISLEFRNLAEKYQTVIADICHRMGCGMAEFLNKDVTSKQDWDKYCHYVAGLVGIGLSRLFSASEFEDPIVGEDTECANSMGLFLQKTNIIRDYLEDQQEGRQFWPQEVWGKYVKKLEDFVKPENVDVAVKCLNELITNALQHIPDVITYLSRLRNQSVFNFCAIPQVMAIATLAACYNNHQVFKGVVKIRKGQAVTLMMDATNMPAVKAIIYQYIEEIYHRVPNSDPSASKAKQLISNIRTQSLPNCQLISRSHYSPIYLSFIMLLAALSWQYLSTLSQVTEDYVQREH
  
Inhibitor
Name:
BDBM50388354
Synonyms:
CHEMBL2057270
Type:
Small organic molecule
Emp. Form.:
C23H22ClNO5
Mol. Mass.:
427.877
SMILES:
COC(=O)CC1OC(c2cccc(OC)c2OC)c2cc(Cl)ccc2-n2cccc12
Structure:
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