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Target
M-phase inducer phosphatase 1
Ligand
BDBM41999
Substrate
n/a
Meas. Tech.
ChEMBL_830419 (CHEMBL2061097)
IC50
330±n/a nM
Citation
 Lavecchia, A; Di Giovanni, C; Pesapane, A; Montuori, N; Ragno, P; Martucci, NM; Masullo, M; De Vendittis, E; Novellino, E Discovery of new inhibitors of Cdc25B dual specificity phosphatases by structure-based virtual screening. J Med Chem 55:4142-58 (2012) [PubMed]  Article 
Target
Name:
M-phase inducer phosphatase 1
Synonyms:
CDC25A | Dual specificity phosphatase (Cdc25A) | Dual specificity phosphatase Cdc25A | M-phase inducer phosphatase 1 | MPIP1_HUMAN | phosphatase Cdc25
Type:
Protein
Mol. Mass.:
59090.18
Organism:
Homo sapiens (Human)
Description:
P30304
Residue:
524
Sequence:
MELGPEPPHRRRLLFACSPPPASQPVVKALFGASAAGGLSPVTNLTVTMDQLQGLGSDYEQPLEVKNNSNLQRMGSSESTDSGFCLDSPGPLDSKENLENPMRRIHSLPQKLLGCSPALKRSHSDSLDHDIFQLIDPDENKENEAFEFKKPVRPVSRGCLHSHGLQEGKDLFTQRQNSAPARMLSSNERDSSEPGNFIPLFTPQSPVTATLSDEDDGFVDLLDGENLKNEEETPSCMASLWTAPLVMRTTNLDNRCKLFDSPSLCSSSTRSVLKRPERSQEESPPGSTKRRKSMSGASPKESTNPEKAHETLHQSLSLASSPKGTIENILDNDPRDLIGDFSKGYLFHTVAGKHQDLKYISPEIMASVLNGKFANLIKEFVIIDCRYPYEYEGGHIKGAVNLHMEEEVEDFLLKKPIVPTDGKRVIVVFHCEFSSERGPRMCRYVRERDRLGNEYPKLHYPELYVLKGGYKEFFMKCQSYCEPPSYRPMHHEDFKEDLKKFRTKSRTWAGEKSKREMYSRLKKL
  
Inhibitor
Name:
BDBM41999
Synonyms:
3-(3,4,5-trihydroxy-6-keto-xanthen-9-yl)propionic acid | 3-(3,4,5-trihydroxy-6-oxo-9-xanthenyl)propanoic acid | 3-(3,4,5-trihydroxy-6-oxoxanthen-9-yl)propanoic acid | 3-[3,4,5-tris(oxidanyl)-6-oxidanylidene-xanthen-9-yl]propanoic acid | MLS-0111617.0001 | cid_274127
Type:
Small organic molecule
Emp. Form.:
C16H12O7
Mol. Mass.:
316.2623
SMILES:
OC(=O)CCc1c2ccc(O)c(O)c2oc2c(O)c(=O)ccc12
Structure:
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