Target
Lysine--tRNA ligase
Ligand
BDBM50390547
Substrate
n/a
Meas. Tech.
ChEMBL_835320 (CHEMBL2072026)
IC50
1671±n/a nM
Citation
 Castillo, MForns, PErra, MMir, MLópez, MMaldonado, MOrellana, ACarreño, CRamis, IMiralpeix, MVidal, B Highly potent aminopyridines as Syk kinase inhibitors. Bioorg Med Chem Lett 22:5419-23 (2012) [PubMed]  Article 
Target
Name:
Lysine--tRNA ligase
Synonyms:
KARS | KARS1 | KIAA0070 | Lysyl-tRNA synthetase | SYK_HUMAN
Type:
PROTEIN
Mol. Mass.:
68044.78
Organism:
Homo sapiens (Human)
Description:
ChEMBL_960665
Residue:
597
Sequence:
MAAVQAAEVKVDGSEPKLSKNELKRRLKAEKKVAEKEAKQKELSEKQLSQATAAATNHTTDNGVGPEEESVDPNQYYKIRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGDHLTDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNKLRRGDIIGVQGNPGKTKKGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFVRQKFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMVSGMVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETRKILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKEGLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYGLPPTAGWGMGIDRVAMFLTDSNNIKEVLLFPAMKPEDKKENVATTDTLESTTVGTSV
  
Inhibitor
Name:
BDBM50390547
Synonyms:
CHEMBL2069339
Type:
Small organic molecule
Emp. Form.:
C18H18N4
Mol. Mass.:
290.3623
SMILES:
Cc1ccnc(Nc2cccc(n2)-c2cccc(CN)c2)c1
Structure:
Search PDB for entries with ligand similarity: