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Target
Lysine--tRNA ligase
Ligand
BDBM50390559
Substrate
n/a
Meas. Tech.
ChEMBL_835320 (CHEMBL2072026)
IC50
43±n/a nM
Citation
 Castillo, M; Forns, P; Erra, M; Mir, M; López, M; Maldonado, M; Orellana, A; Carreño, C; Ramis, I; Miralpeix, M; Vidal, B Highly potent aminopyridines as Syk kinase inhibitors. Bioorg Med Chem Lett 22:5419-23 (2012) [PubMed]  Article 
Target
Name:
Lysine--tRNA ligase
Synonyms:
KARS | KARS1 | KIAA0070 | Lysyl-tRNA synthetase | SYK_HUMAN
Type:
PROTEIN
Mol. Mass.:
68044.78
Organism:
Homo sapiens (Human)
Description:
ChEMBL_960665
Residue:
597
Sequence:
MAAVQAAEVKVDGSEPKLSKNELKRRLKAEKKVAEKEAKQKELSEKQLSQATAAATNHTTDNGVGPEEESVDPNQYYKIRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGDHLTDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNKLRRGDIIGVQGNPGKTKKGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFVRQKFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMVSGMVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETRKILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKEGLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYGLPPTAGWGMGIDRVAMFLTDSNNIKEVLLFPAMKPEDKKENVATTDTLESTTVGTSV
  
Inhibitor
Name:
BDBM50390559
Synonyms:
CHEMBL2069348
Type:
Small organic molecule
Emp. Form.:
C19H20N6
Mol. Mass.:
332.4023
SMILES:
C1CN(CCN1)c1cccc(c1)-c1cccc(Nc2cnccn2)n1
Structure:
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