Target
Lysine--tRNA ligase
Ligand
BDBM50390565
Substrate
n/a
Meas. Tech.
ChEMBL_835320 (CHEMBL2072026)
IC50
28±n/a nM
Citation
 Castillo, MForns, PErra, MMir, MLópez, MMaldonado, MOrellana, ACarreño, CRamis, IMiralpeix, MVidal, B Highly potent aminopyridines as Syk kinase inhibitors. Bioorg Med Chem Lett 22:5419-23 (2012) [PubMed]  Article 
Target
Name:
Lysine--tRNA ligase
Synonyms:
KARS | KARS1 | KIAA0070 | Lysyl-tRNA synthetase | SYK_HUMAN
Type:
PROTEIN
Mol. Mass.:
68044.78
Organism:
Homo sapiens (Human)
Description:
ChEMBL_960665
Residue:
597
Sequence:
MAAVQAAEVKVDGSEPKLSKNELKRRLKAEKKVAEKEAKQKELSEKQLSQATAAATNHTTDNGVGPEEESVDPNQYYKIRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGDHLTDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNKLRRGDIIGVQGNPGKTKKGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFVRQKFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMVSGMVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETRKILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKEGLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYGLPPTAGWGMGIDRVAMFLTDSNNIKEVLLFPAMKPEDKKENVATTDTLESTTVGTSV
  
Inhibitor
Name:
BDBM50390565
Synonyms:
CHEMBL2069354
Type:
Small organic molecule
Emp. Form.:
C25H24N8O
Mol. Mass.:
452.5111
SMILES:
O=C(Nc1cc(Nc2cnccn2)nc(c1)-c1ccnc(c1)N1CCNCC1)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: