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Target
Oxysterols receptor LXR-beta
Ligand
BDBM50390746
Substrate
n/a
Meas. Tech.
ChEMBL_835704 (CHEMBL2071815)
IC50
2500±n/a nM
Citation
 Jiao, X; Kopecky, DJ; Fisher, B; Piper, DE; Labelle, M; McKendry, S; Harrison, M; Jones, S; Jaen, J; Shiau, AK; Escaron, P; Danao, J; Chai, A; Coward, P; Kayser, F Discovery and optimization of a series of liver X receptor antagonists. Bioorg Med Chem Lett 22:5966-70 (2012) [PubMed]  Article 
Target
Name:
Oxysterols receptor LXR-beta
Synonyms:
LXRB | Liver X receptor beta (NR1H2) | Liver X, LXR beta | NER | NR1H2 | NR1H2_HUMAN | Nuclear receptor NER | UNR | Ubiquitously-expressed nuclear receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50978.79
Organism:
Homo sapiens (Human)
Description:
P55055
Residue:
460
Sequence:
MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
  
Inhibitor
Name:
BDBM50390746
Synonyms:
CHEMBL2070369
Type:
Small organic molecule
Emp. Form.:
C27H23F6NO3S
Mol. Mass.:
555.532
SMILES:
CC(C)CN(c1ccc(cc1)C(O)(C#Cc1ccc(cc1)C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1
Structure:
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