Reaction Details Report a problem with these data
Target
Translocator protein
Ligand
BDBM50390840
Substrate
n/a
Meas. Tech.
ChEMBL_835804 (CHEMBL2071915)
Ki
0.19±n/a nM
Citation
 Wadsworth, H; Jones, PA; Chau, WF; Durrant, C; Morisson-Iveson, V; Passmore, J; O'Shea, D; Wynn, D; Khan, I; Black, A; Avory, M; Trigg, W Exploration of the structure-activity relationship of the diaryl anilide class of ligands for translocator protein--potential novel positron emitting tomography imaging agents. Bioorg Med Chem Lett 22:5795-800 (2012) [PubMed]  Article 
Target
Name:
Translocator protein
Synonyms:
Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:
Mitochondrion membrane protein
Mol. Mass.:
18945.84
Organism:
Rattus norvegicus (rat)
Description:
Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:
169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAMGYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVATATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
  
Inhibitor
Name:
BDBM50390840
Synonyms:
CHEMBL2070786
Type:
Small organic molecule
Emp. Form.:
C24H23F2NO4
Mol. Mass.:
427.4405
SMILES:
COc1ccc(OCCF)cc1CN(C(C)=O)c1cc(F)ccc1Oc1ccccc1
Structure:
Search PDB for entries with ligand similarity: