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Target
ATP-sensitive inward rectifier potassium channel 11
Ligand
BDBM50357205
Substrate
n/a
Meas. Tech.
ChEMBL_857216 (CHEMBL2160412)
IC50
>5000±n/a nM
Citation
 Lowes, D; Pradhan, A; Iyer, LV; Parman, T; Gow, J; Zhu, F; Furimsky, A; Lemoff, A; Guiguemde, WA; Sigal, M; Clark, JA; Wilson, E; Tang, L; Connelly, MC; Derisi, JL; Kyle, DE; Mirsalis, J; Guy, RK Lead optimization of antimalarial propafenone analogues. J Med Chem 55:6087-93 (2012) [PubMed]  Article 
Target
Name:
ATP-sensitive inward rectifier potassium channel 11
Synonyms:
ATP-sensitive inward rectifier potassium channel 11 | IKATP | Inward rectifier K(+) channel Kir6.2 | KCJ11_HUMAN | KCNJ11 | Potassium channel, inwardly rectifying subfamily J member 11 | Potassium channel, inwardly rectifying, subfamily J, member 11 | Sulfonylurea receptor 1, Kir6.2 | Sulfonylurea receptor 2, Kir6.2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
43549.41
Organism:
Homo sapiens (Human)
Description:
Potassium channel (ATP modulatory) 0 0::Q14654
Residue:
390
Sequence:
MLSRKGIIPEEYVLTRLAEDPAEPRYRARQRRARFVSKKGNCNVAHKNIREQGRFLQDVFTTLVDLKWPHTLLIFTMSFLCSWLLFAMAWWLIAFAHGDLAPSEGTAEPCVTSIHSFSSAFLFSIEVQVTIGFGGRMVTEECPLAILILIVQNIVGLMINAIMLGCIFMKTAQAHRRAETLIFSKHAVIALRHGRLCFMLRVGDLRKSMIISATIHMQVVRKTTSPEGEVVPLHQVDIPMENGVGGNSIFLVAPLIIYHVIDANSPLYDLAPSDLHHHQDLEIIVILEGVVETTGITTQARTSYLADEILWGQRFVPIVAEEDGRYSVDYSKFGNTIKVPTPLCTARQLDEDHSLLEALTLASARGPLRKRSVPMAKAKPKFSISPDSLS
  
Inhibitor
Name:
BDBM50357205
Synonyms:
CHEMBL1914844 | CHEMBL1963594
Type:
Small organic molecule
Emp. Form.:
C29H34N2O3
Mol. Mass.:
458.5919
SMILES:
Cc1ccc(cc1)N1CCN(CC(O)COc2ccccc2C(=O)CCc2ccccc2)CC1
Structure:
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