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Target
Acetylcholinesterase
Ligand
BDBM8961
Substrate
n/a
Meas. Tech.
ChEMBL_857652 (CHEMBL2168279)
IC50
50±n/a nM
Citation
 Trinh Thi Thanh, V; Doan Thi Mai, H; Pham, VC; Litaudon, M; Dumontet, V; Guéritte, F; Nguyen, VH; Chau, VM Acetylcholinesterase inhibitors from the leaves of Macaranga kurzii. J Nat Prod 75:2012-2015 (2012) [PubMed]  Article 
Target
Name:
Acetylcholinesterase
Synonyms:
Acetylcholinesterase (AChE) | Acetylcholinesterase (EeAChE) | ACES_ELEEL | ache
Type:
Enzyme
Mol. Mass.:
71812.79
Organism:
Electric eel
Description:
n/a
Residue:
633
Sequence:
MKILDALLFPVIFIMFFIHLSIAQTDPELTIMTRLGQVQGTRLPVPDRSHVIAFLGIPFAEPPLGKMRFKPPEPKKPWNDVFDARDYPSACYQYVDTSYPGFSGTEMWNPNRMMSEDCLYLNVWVPATPRPHNLTVMVWIYGGGFYSGSSSLDVYDGRYLAHSEKVVVVSMNYRVSAFGFLALNGSAEAPGNVGLLDQRLALQWVQDNIHFFGGNPKQVTIFGESAGAASVGMHLLSPDSRPKFTRAILQSGVPNGPWRTVSFDEARRRAIKLGRLVGCPDGNDTDLIDCLRSKQPQDLIDQEWLVLPFSGLFRFSFVPVIDGVVFPDTPEAMLNSGNFKDTQILLGVNQNEGSYFLIYGAPGFSKDNESLITREDFLQGVKMSVPHANEIGLEAVILQYTDWMDEDNPIKNREAMDDIVGDHNVVCPLQHFAKMYAQYSILQGQTGTASQGNLGWGNSGSASNSGNSQVSVYLYMFDHRASNLVWPEWMGVIHGYEIEFVFGLPLEKRLNYTLEEEKLSRRMMKYWANFARTGNPNINVDGSIDSRRRWPVFTSTEQKHVGLNTDSLKVHKGLKSQFCALWNRFLPRLLNVTENIDDAERQWKAEFHRWSSYMMHWKNQFDHYSKQERCTNL
  
Inhibitor
Name:
BDBM8961
Synonyms:
CHEMBL95 | Cognex | cid_1935 | CHEMBL1337960 | 1,2,3,4-tetrahydroacridin-9-amine | Tracine | tacrine.HCl | 9-THA | 1,2,3,4-tetrahydro-9-acridinamine | 9-amino-1,2,3,4-tetrahydroacridine (THA) | Tacrine | US8999994, Tacrine
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: