Reaction Details Report a problem with these data
Target
Hexokinase-4
Ligand
BDBM50394681
Substrate
n/a
Meas. Tech.
ChEMBL_858381 (CHEMBL2168596)
EC50
6900±n/a nM
Citation
Pfefferkorn, JA; Guzman-Perez, A; Litchfield, J; Aiello, R; Treadway, JL; Pettersen, J; Minich, ML; Filipski, KJ; Jones, CS; Tu, M; Aspnes, G; Risley, H; Bian, J; Stevens, BD; Bourassa, P; D'Aquila, T; Baker, L; Barucci, N; Robertson, AS; Bourbonais, F; Derksen, DR; Macdougall, M; Cabrera, O; Chen, J; Lapworth, AL; Landro, JA; Zavadoski, WJ; Atkinson, K; Haddish-Berhane, N; Tan, B; Yao, L; Kosa, RE; Varma, MV; Feng, B; Duignan, DB; El-Kattan, A; Murdande, S; Liu, S; Ammirati, M; Knafels, J; Dasilva-Jardine, P; Sweet, L; Liras, S; Rolph, TP Discovery of (S)-6-(3-cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid as a hepatoselective glucokinase activator clinical candidate for treating type 2 diabetes mellitus. J Med Chem 55:1318-33 (2012) [PubMed] Article
More Info.:
Target
Name:
Hexokinase-4
Synonyms:
Gck | HXK4_RAT | Hexokinase type IV
Type:
PROTEIN
Mol. Mass.:
52101.81
Organism:
Rattus norvegicus
Description:
ChEMBL_1279785
Residue:
465
Sequence:
MLDDRARMEATKKEKVEQILAEFQLQEEDLKKVMSRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEAGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDLDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRMVDESSANPGQQLYEKIIGGKYMGELVRLVLLKLVDENLLFHGEASEQLRTRGAFETRFVSQVESDSGDRKQIHNILSTLGLRPSVTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPNCEITFIESEEGSGRGAALVSAVACKKACMLAQ