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Target
Protein kinase C iota type
Ligand
BDBM50395892
Substrate
n/a
Meas. Tech.
ChEMBL_858039 (CHEMBL2166775)
Ki
>1000000±n/a nM
Citation
 Tell, V; Holzer, M; Herrmann, L; Mahmoud, KA; Schächtele, C; Totzke, F; Hilgeroth, A Multitargeted drug development: Discovery and profiling of dihydroxy substituted 1-aza-9-oxafluorenes as lead compounds targeting Alzheimer disease relevant kinases. Bioorg Med Chem Lett 22:6914-8 (2012) [PubMed]  Article 
Target
Name:
Protein kinase C iota type
Synonyms:
Protein kinase C iota | aPKC-lambda/iota | PRKC-lambda/iota | Atypical protein kinase C-lambda/iota | Protein kinase C (PKC) | Protein kinase C iota type | nPKC-iota | KPCI_HUMAN | PRKCI | DXS1179E | Protein kinase C iota type/zeta type | Protein kinase C iota (PKCι)
Type:
Enzyme
Mol. Mass.:
68251.56
Organism:
Human
Description:
P41743
Residue:
596
Sequence:
MPTQRDSSTMSHTVAGGGSGDHSHQVRVKAYYRGDIMITHFEPSISFEGLCNEVRDMCSFDNEQLFTMKWIDEEGDPCTVSSQLELEEAFRLYELNKDSELLIHVFPCVPERPGMPCPGEDKSIYRRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKLVTIECGRHSLPQEPVMPMDQSSMHSDHAQTVIPYNPSSHESLDQVGEEKEAMNTRESGKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPLLMSAEECV
  
Inhibitor
Name:
BDBM50395892
Synonyms:
CHEMBL2163772
Type:
Small organic molecule
Emp. Form.:
C17H11NO3
Mol. Mass.:
n/a
SMILES:
Oc1ccc2oc3ncc(O)c(-c4ccccc4)c3c2c1
Structure:
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