Reaction Details Report a problem with these data
Target
Proteasome subunit beta type-5
Ligand
BDBM50398609
Substrate
n/a
Meas. Tech.
ChEMBL_874481 (CHEMBL2184804)
IC50
3.4±n/a nM
Citation
 Kale, AJ; Moore, BS Molecular mechanisms of acquired proteasome inhibitor resistance. J Med Chem 55:10317-27 (2012) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-5
Synonyms:
20S proteasome chymotrypsin-like | 26S proteosome | LMPX | MB1 | PSB5_HUMAN | PSMB5 | Proteasome Macropain subunit MB1 | Proteasome subunit beta type-1/beta type-5 | X
Type:
Protein
Mol. Mass.:
28480.96
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
263
Sequence:
MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGTTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVADLHEKYSGSTP
  
Inhibitor
Name:
BDBM50398609
Synonyms:
CHEMBL2141296 | IXAZOMIB CITRATE | Ixazomib | MLN2238 | NINLARO
Type:
Small organic molecule
Emp. Form.:
C14H19BCl2N2O4
Mol. Mass.:
361.029
SMILES:
CC(C)C[C@H](NC(=O)CNC(=O)c1cc(Cl)ccc1Cl)B(O)O
Structure:
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