Reaction Details Report a problem with these data
Target
Bombesin receptor subtype-3
Ligand
BDBM50394618
Substrate
n/a
Meas. Tech.
ChEMBL_872477 (CHEMBL2182517)
EC50
>10000±n/a nM
Citation
 Liu, P; Lanza, TJ; Chioda, M; Jones, C; Chobanian, HR; Guo, Y; Chang, L; Kelly, TM; Kan, Y; Palyha, O; Guan, XM; Marsh, DJ; Metzger, JM; Ramsay, K; Wang, SP; Strack, AM; Miller, R; Pang, J; Lyons, K; Dragovic, J; Ning, JG; Schafer, WA; Welch, CJ; Gong, X; Gao, YD; Hornak, V; Ball, RG; Tsou, N; Reitman, ML; Wyvratt, MJ; Nargund, RP; Lin, LS Discovery of benzodiazepine sulfonamide-based bombesin receptor subtype 3 agonists and their unusual chirality. ACS Med Chem Lett 2:933-937 (2011) [PubMed]  Article 
Target
Name:
Bombesin receptor subtype-3
Synonyms:
BRS3_MOUSE | Brs3
Type:
PROTEIN
Mol. Mass.:
44239.49
Organism:
Mouse
Description:
ChEMBL_1445902
Residue:
399
Sequence:
MSQRQSQSPNQTLISITNDTETSSSVVSNDTTHKGWTGDNSPGIEALCAIYITYAGIISVGILGNAILIKVFFKTKSMQTVPNIFITSLAFGDLLLLLTCVPVDATHYLAEGWLFGKVGCKVLSFIRLTSVGVSVFTLTILSADRYKAVVKPLERQPPNAILKTCAKAGGIWIVSMIFALPEAIFSNVYTFQDPNRNVTFESCNSYPISERLLQEIHSLLCFLVFYIIPLSIISVYYSLIARTLYKSTLNIPTEEQSHARKQIESRKRIAKTVLVLVALFALCWLPNHLLYLYHSFTYESYANHSDVPFVIIIFSRVLAFSNSCVNPFALYWLSKTFQQHFKAQLCCLKAEQPEPPLGDIPLNNLTVMGRVPATGSAHVSEISVTLFSGSSAKKGEDKV
  
Inhibitor
Name:
BDBM50394618
Synonyms:
CHEMBL2164575
Type:
Small organic molecule
Emp. Form.:
C25H26F3N3O2S
Mol. Mass.:
n/a
SMILES:
Cc1ccc2Nc3nc(ccc3CN(c2c1C)S(=O)(=O)c1ccc(cc1)C(C)(C)C)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: