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Target
C-C chemokine receptor type 5
Ligand
BDBM50400792
Substrate
n/a
Meas. Tech.
ChEMBL_879200
IC50
17±n/a nM
Citation
 Armour, DR; de Groot, MJ; Price, DA; Stammen, BL; Wood, A; Perros, M; Burt, C The discovery of tropane-derived CCR5 receptor antagonists. Chem Biol Drug Des 67:305-8 (2006) [PubMed]  Article  BDB Entry
Target
Name:
C-C chemokine receptor type 5
Synonyms:
C-C CKR-5 | C-C chemokine receptor type 5 | CC-CKR-5 | CCR-5 | CCR5 | CCR5/mu opioid receptor complex | CD_antigen=CD195 | CHEMR13 | HIV-1 fusion coreceptor
Type:
Enzyme
Mol. Mass.:
40540.21
Organism:
Homo sapiens (Human)
Description:
P51681
Residue:
352
Sequence:
MDYQVSSPIYDINYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKRLKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAVVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGLHYTCSSHFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL
  
Inhibitor
Name:
BDBM50400792
Synonyms:
CHEMBL2203618
Type:
Small organic molecule
Emp. Form.:
C27H32N4O
Mol. Mass.:
428.5692
SMILES:
Cc1nc2ccccc2n1C1[C@H]2CN(CC[C@H](NC(=O)C3CCC3)c3ccccc3)C[C@@H]12 |r|
Structure:
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