Reaction Details Report a problem with these data
Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM50004656
Substrate
n/a
Meas. Tech.
ChEMBL_882194 (CHEMBL2215467)
EC50
250±n/a nM
Citation
 Daval, SB; Valant, C; Bonnet, D; Kellenberger, E; Hibert, M; Galzi, JL; Ilien, B Fluorescent derivatives of AC-42 to probe bitopic orthosteric/allosteric binding mechanisms on muscarinic M1 receptors. J Med Chem 55:2125-43 (2012) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1 | ACM1_HUMAN | CHRM1
Type:
Protein
Mol. Mass.:
51442.54
Organism:
Human
Description:
P11229
Residue:
460
Sequence:
MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM50004656
Synonyms:
(2-Hydroxyethyl)trimethyl ammonium chloride carbamate | Choline chlorine carbamate | 2-((Aminocarbonyl)oxy)-N,N,N-trimethylethanaminum chloride | (2-Carbamoyloxyethyl)trimethylammonium chloride | Karbachol | Carbachol chloride | (2-Hydroxyethyl)trimethylammonium chloride carbamate | (carbachol)(2-Carbamoyloxy-ethyl)-trimethyl-ammonium | CHEMBL14 | CARBASTAT | Karbamoylcholin chlorid | 2-((Aminocarbonyl)oxy)-N,N,N-trimethylethanaminium chloride | 2-(carbamoyloxy)-N,N,N-trimethylethanaminium | MIOSTAT | Choline carbamate chloride | CARBACHOL | Choline chloride, carbamate | (2-Carbamoyloxy-ethyl)-trimethyl-ammonium | Carbamylcholine | 2-(carbamoyloxy)-N,N,N-trimethylethanaminium chloride
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
C[N+](C)(C)CCOC(=O)N
Structure:
Search PDB for entries with ligand similarity: