Reaction Details Report a problem with these data
Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM50326219
Substrate
n/a
Meas. Tech.
ChEMBL_882409 (CHEMBL2210236)
EC50
720±n/a nM
Citation
 Daval, SB; Valant, C; Bonnet, D; Kellenberger, E; Hibert, M; Galzi, JL; Ilien, B Fluorescent derivatives of AC-42 to probe bitopic orthosteric/allosteric binding mechanisms on muscarinic M1 receptors. J Med Chem 55:2125-43 (2012) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1 | ACM1_HUMAN | CHRM1
Type:
Protein
Mol. Mass.:
51442.54
Organism:
Human
Description:
P11229
Residue:
460
Sequence:
MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM50326219
Synonyms:
CHEMBL1242950 | CHEMBL2206334 | 4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one
Type:
Small organic molecule
Emp. Form.:
C20H31NO
Mol. Mass.:
n/a
SMILES:
CCCCC1CCN(CCCC(=O)c2ccccc2C)CC1
Structure:
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