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Target
Carnitine O-palmitoyltransferase 2, mitochondrial
Ligand
BDBM50403040
Substrate
n/a
Meas. Tech.
ChEMBL_887417 (CHEMBL2217026)
IC50
740±n/a nM
Citation
 Ceccarelli, SM; Chomienne, O; Gubler, M; Arduini, A Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research. J Med Chem 54:3109-52 (2011) [PubMed]  Article 
Target
Name:
Carnitine O-palmitoyltransferase 2, mitochondrial
Synonyms:
CPT II | CPT1 | CPT2 | CPT2_HUMAN | Carnitine O-palmitoyltransferase 2, mitochondrial | Carnitine palmitoyltransferase 2 | Carnitine palmitoyltransferase II
Type:
PROTEIN
Mol. Mass.:
73789.25
Organism:
Homo sapiens (Human)
Description:
ChEMBL_887455
Residue:
658
Sequence:
MVPRLLLRAWPRGPAVGPGAPSRPLSAGSGPGQYLQRSIVPTMHYQDSLPRLPIPKLEDTIRRYLSAQKPLLNDGQFRKTEQFCKSFENGIGKELHEQLVALDKQNKHTSYISGPWFDMYLSARDSVVLNFNPFMAFNPDPKSEYNDQLTRATNMTVSAIRFLKTLRAGLLEPEVFHLNPAKSDTITFKRLIRFVPSSLSWYGAYLVNAYPLDMSQYFRLFNSTRLPKPSRDELFTDDKARHLLVLRKGNFYIFDVLDQDGNIVSPSEIQAHLKYILSDSSPAPEFPLAYLTSENRDIWAELRQKLMSSGNEESLRKVDSAVFCLCLDDFPIKDLVHLSHNMLHGDGTNRWFDKSFNLIIAKDGSTAVHFEHSWGDGVAVLRFFNEVFKDSTQTPAVTPQSQPATTDSTVTVQKLNFELTDALKTGITAAKEKFDATMKTLTIDCVQFQRGGKEFLKKQKLSPDAVAQLAFQMAFLRQYGQTVATYESCSTAAFKHGRTETIRPASVYTKRCSEAFVREPSRHSAGELQQMMVECSKYHGQLTKEAAMGQGFDRHLFALRHLAAAKGIILPELYLDPAYGQINHNVLSTSTLSSPAVNLGGFAPVVSDGFGVGYAVHDNWIGCNVSSYPGRNAREFLQCVEKALEDMFDALEGKSIKS
  
Inhibitor
Name:
BDBM50403040
Synonyms:
CHEMBL2216779
Type:
Small organic molecule
Emp. Form.:
C23H19ClN2O6S
Mol. Mass.:
486.925
SMILES:
COc1ccc(Cl)cc1S(=O)(=O)N1CCc2ccc(cc12)C(=O)Nc1ccc(cc1)C(O)=O
Structure:
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