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Target
5-hydroxytryptamine receptor 3A/3B
Ligand
BDBM50108392
Substrate
n/a
Meas. Tech.
ChEMBL_3117 (CHEMBL617960)
Kd
0.794328±n/a nM
Citation
 Blum, E; Buchheit, K; Buescher, H; Gamse, R; Kloeppner, E; Meigel, H; Papageorgiou, C; Waelchli, R; Revesz, L Design and synthesis of novel ligands for the 5-HT3 and the 5-HT4 receptor Bioorg Med Chem Lett 2:461-466 (1992)    Article 
Target
Name:
5-hydroxytryptamine receptor 3A/3B
Synonyms:
Serotonin 3 receptor (5HT3)
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of ChEMBL is 357762
Components:
This complex has 2 components.
Component 1
Name:
5-hydroxytryptamine receptor 3A
Synonyms:
Serotonin-gated ion channel receptor | 5-HT-3 | 5-HT3R | Serotonin 3 receptor (5HT3) | Serotonin 3a (5-HT3a) receptor | 5-HT3-A | 5-hydroxytryptamine receptor 3 | 5-hydroxytryptamine receptor 3A | 5-HT3A | Serotonin receptor 3A | 5-HT3A Serotonin Receptor | 5HT3A_MOUSE | Htr3a | 5ht3 | Htr3
Type:
n/a
Mol. Mass.:
56056.00
Organism:
Mouse
Description:
5HT3A
Residue:
487
Sequence:
MRLCIPQVLLALFLSMLTAPGEGSRRRATQEDTTQPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILCLGEQPMAHRPPATFQANKTDDCSGSDLLPAMGNHCSHVGGPQDLEKTPRGRGSPLPPPREASLAVRGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHYS
  
Component 2
Name:
5-hydroxytryptamine receptor 3B
Synonyms:
Serotonin 3b (5-HT3b) receptor | 5HT3B_MOUSE | Htr3b | Serotonin 3 receptor (5HT3)
Type:
PROTEIN
Mol. Mass.:
50317.35
Organism:
Mouse
Description:
ChEMBL_3121
Residue:
437
Sequence:
MILLWSCLLVAVVGILGTATPQPGNSSLHRLTRQLLQQYHKEVRPVYNWAEATTVYLDLCVHAVLDVDVQNQKLKTSVWYREVWNDEFLSWNSSLFDEIQEISLPLSALWAPDIIINEFVDVERSPDLPYVYVNSSGTIRNHKPIQVVSACSLQTYAFPFDIQNCSLTFNSILHTVEDIDLGFLRNREDIENDKRAFMNDSEWQLLSVSSTYHIRQSSAGDFAQIRFNVVIRRCPLAYVVSLLIPSIFLMLVDLGSFYLPPNCRARIVFKTNVLVGYTVFRVNMSDEVPRSAGCTPLIGVFFTVCMALLVLSLSKSILLIKFLYEERHSGQERPLMCLQGDSDAEESRLYLGAPRADVTESPVHQEHRVPSDTLKDFWFQFRSINNSLRTRDQIHQKEVEWLAILYRFDQLLFRIYLAVLGLYTVTLCSLWALWSRM
  
Inhibitor
Name:
BDBM50108392
Synonyms:
(3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-INDOLE-3-CARBOXYLATE | CHEMBL56564
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: