Reaction Details Report a problem with these data
Target
Dihydrofolate reductase
Ligand
BDBM18069
Substrate
n/a
Meas. Tech.
ChEMBL_54557 (CHEMBL857513)
Ki
1.3±n/a nM
Citation
Johnson, JV; Rauchman, BS; Baccanari, DP; Roth, B 2,4-Diamino-5-benzylpyrimidines and analogues as antibacterial agents. 12. 1,2-Dihydroquinolylmethyl analogues with high activity and specificity for bacterial dihydrofolate reductase. J Med Chem 32:1942-9 (1989) [PubMed] Article
More Info.:
Target
Name:
Dihydrofolate reductase
Synonyms:
Dihydrofolate reductase (F31V) | dfrA17
Type:
n/a
Mol. Mass.:
17532.46
Organism:
Escherichia coli
Description:
n/a
Residue:
157
Sequence:
MKISLISAVSESGVIGSGPDIPWSVKGEQLLFKALTYNQWLLVGRKTFDSMGVLPNRKYAVVSKNGISSSNENVLVFPSIENALKELSKVTDHVYVSGGGQIYNSLIEKADIIHLSTVHVEVEGDIKFPIMPENFNLVFEQFFMSNINYTYQIWKKG