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Target
5-hydroxytryptamine receptor 3A/3B
Ligand
BDBM48320
Substrate
n/a
Meas. Tech.
ChEMBL_3112 (CHEMBL620590)
Kd
224±n/a nM
Citation
 Hibert, MF; Hoffmann, R; Miller, RC; Carr, AA Conformation-activity relationship study of 5-HT3 receptor antagonists and a definition of a model for this receptor site. J Med Chem 33:1594-600 (1990) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 3A/3B
Synonyms:
Serotonin 3 receptor (5HT3)
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of ChEMBL is 357762
Components:
This complex has 2 components.
Component 1
Name:
5-hydroxytryptamine receptor 3A
Synonyms:
Serotonin-gated ion channel receptor | 5-HT-3 | 5-HT3R | Serotonin 3 receptor (5HT3) | Serotonin 3a (5-HT3a) receptor | 5-HT3-A | 5-hydroxytryptamine receptor 3 | 5-hydroxytryptamine receptor 3A | 5-HT3A | Serotonin receptor 3A | 5-HT3A Serotonin Receptor | 5HT3A_MOUSE | Htr3a | 5ht3 | Htr3
Type:
n/a
Mol. Mass.:
56056.00
Organism:
Mouse
Description:
5HT3A
Residue:
487
Sequence:
MRLCIPQVLLALFLSMLTAPGEGSRRRATQEDTTQPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILCLGEQPMAHRPPATFQANKTDDCSGSDLLPAMGNHCSHVGGPQDLEKTPRGRGSPLPPPREASLAVRGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHYS
  
Component 2
Name:
5-hydroxytryptamine receptor 3B
Synonyms:
Serotonin 3b (5-HT3b) receptor | 5HT3B_MOUSE | Htr3b | Serotonin 3 receptor (5HT3)
Type:
PROTEIN
Mol. Mass.:
50317.35
Organism:
Mouse
Description:
ChEMBL_3121
Residue:
437
Sequence:
MILLWSCLLVAVVGILGTATPQPGNSSLHRLTRQLLQQYHKEVRPVYNWAEATTVYLDLCVHAVLDVDVQNQKLKTSVWYREVWNDEFLSWNSSLFDEIQEISLPLSALWAPDIIINEFVDVERSPDLPYVYVNSSGTIRNHKPIQVVSACSLQTYAFPFDIQNCSLTFNSILHTVEDIDLGFLRNREDIENDKRAFMNDSEWQLLSVSSTYHIRQSSAGDFAQIRFNVVIRRCPLAYVVSLLIPSIFLMLVDLGSFYLPPNCRARIVFKTNVLVGYTVFRVNMSDEVPRSAGCTPLIGVFFTVCMALLVLSLSKSILLIKFLYEERHSGQERPLMCLQGDSDAEESRLYLGAPRADVTESPVHQEHRVPSDTLKDFWFQFRSINNSLRTRDQIHQKEVEWLAILYRFDQLLFRIYLAVLGLYTVTLCSLWALWSRM
  
Inhibitor
Name:
BDBM48320
Synonyms:
SMR000058471 | METOCLOPRAMIDE | METOCLOPRAMIDE HYDROCHLORIDE | 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide;hydrochloride | MLS000069667 | 4-azanyl-5-chloranyl-N-[2-(diethylamino)ethyl]-2-methoxy-benzamide;hydrochloride | cid_23659 | 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxy-benzamide;hydrochloride | US9132134, Metoclopramide | Metochloropramide | US11147820, Compound Metoclopramide | US11717500, Compound Metoclopramide
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: