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Target
3-oxo-5-alpha-steroid 4-dehydrogenase 1
Ligand
BDBM50057498
Substrate
n/a
Meas. Tech.
ChEMBL_204884 (CHEMBL857530)
Ki
>2500±n/a nM
Citation
 Holt, DA; Yamashita, DS; Konialian-Beck, AL; Luengo, JI; Abell, AD; Bergsma, DJ; Brandt, M; Levy, MA Benzophenone- and indolecarboxylic acids: potent type-2 specific inhibitors of human steroid 5 alpha-reductase. J Med Chem 38:13-5 (1995) [PubMed]  Article 
Target
Name:
3-oxo-5-alpha-steroid 4-dehydrogenase 1
Synonyms:
3-oxo-5-alpha-steroid 4-dehydrogenase 1 | 5α-Reductase 1 (5α-R1) | S5A1_HUMAN | S5AR | SR type 1 | SRD5A1 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 1
Type:
Enzyme
Mol. Mass.:
29472.80
Organism:
Homo sapiens (Human)
Description:
P18405
Residue:
259
Sequence:
MATATGVAEERLLAALAYLQCAVGCAVFARNRQTNSVYGRHALPSHRLRVPARAAWVVQELPSLALPLYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMRGGKPMPLLACTMAIMFCTCNGYLQSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRKPGDTGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEWYLRKFEEYPKFRKIIIPFLF
  
Inhibitor
Name:
BDBM50057498
Synonyms:
5-Benzyloxy-1H-indole-2-carboxylic acid | CHEMBL24850
Type:
Small organic molecule
Emp. Form.:
C16H13NO3
Mol. Mass.:
267.2793
SMILES:
OC(=O)c1cc2cc(OCc3ccccc3)ccc2[nH]1
Structure:
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